For more than 20 years, the goal of the Columbia Center for Children’s Environmental Health (CCCEH) has been to identify toxic contaminants and harmful pollutants that compromise the health and brain development of young children. In addition to measuring prenatal and post-natal exposures to environmental chemicals and air pollutants, we assess psychosocial stress and evaluate the effects of climate change as co-exposures that adversely affect child health. Our findings include increased risk of asthma, cognitive and behavioral disorders, and obesity related to these toxic exposures. Our partnerships with non-profit groups in Northern Manhattan, the South Bronx and New York City and our educational and media outreach activities ensure that we effectively communicate our findings to parents, the community and to policymakers in order to protect children’s health.